Darin,
I'm running Creo 2.0 M100 and Windchill 10.1 M030 on an HP laptop with Windows 7 Pro 64x SP1, Adobe Flash Player 12, and Java 7 Update 55.
We were warned to NOT install Internet Explorer 11 because Windchill would stop working from within Creo. Creo uses IE as its embedded browser to access Windchill. So, I'm still running IE 10.0.9200.16899 with update version 10.0.16.
I'd check to make sure you're NOT running IE 11.